Some of the most popular drugs on the market—including prescription and OTC options—can also cause debilitating tiredness. Could your medication pills be the reason you cannot seem to make it through the day without multiple cups of coffee? Here are the 4 common medications that are likely sucking the energy out of you.

1. Antidepressants - Most modern antidepressants (SSRIs, or selective serotonin reuptake inhibitors) work by regulating serotonin, a mood chemical in the brain that plays an important role in sleep. Although SSRIs tend to be less sedating than older antidepressants (including tricyclics such as Elavil), some people still end up feeling sluggish.

2. Antihistamines - Histamine gives you energy and helps your brain function normally, says Simpkins. When you block it, you block the allergic reaction, but you are also blocking the normal functioning of the brain. Hence, the sleepiness.

3. Blood pressure medication - Beta blockers inhibit the production of adrenaline, a hormone that causes your heart to beat rapidly. By slowing your heart rate, they lower the force of the blood pounding on your artery walls (aka your blood pressure). But having less adrenaline can also zap your energy level. One beta blocker, Inderal, is particularly fatiguing, says Nancy Simpkins, MD, a board-certified internist who specializes in womens health and practices in Livingston, NJ.

4. Anti-anxiety medications - These drugs bind to a receptor in the brain that releases a chemical called GABA. When GABA is released, it signals the brain and body to relax, which can provide short-term relief to someone with intense anxiety. But it may also work a little too well, causing you to become drowsy or even fall asleep.


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