Researchers say they have gained new insight into how the immune system restores itself during sleep. Blood samples were taken from 14 healthy young men, average age 25 when they slept through the night and again when they stayed awake all night. The samples were analyzed for levels of T-cells, which are white blood cells that are the foundation of the immune system.

When the participants got a full nights sleep, levels of all types of T-cells fell within three hours of falling asleep. But T-cell levels stayed high when the volunteers stayed awake all night.

It is not clear where T-cells went when they left the bloodstream during sleep. But, previous research suggests they may accumulate in lymph nodes, according to the authors of the study published recently in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology.

The rapid fall in T-cell levels in the blood during sleep shows that even one night without sleep affects the adaptive immune system and that might be one reason why regular sleep is so important for general healthstudy first author Luciana Besedovsky said in a journal news release.

Besedovsky is a researcher in the Department of Medical Psychology and Behavioral Neurobiology at the University of Tubingen in Germany.


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