A recent study published in the American Journal of Clinical Nutrition examined the effectiveness of a weight loss program among more than 1200 overweight and obese people in Spain and found that eating lunch later than 3 PM resulted in less weight loss.

The study looked specifically at the perilipin protein, which is found in human cells and is essential in moving and burning fat throughout the body. People with a specific genetic variation of this protein lost less weight when they ate lunch later than 3 PM compared to people who ate lunch earlier than 3. (Lunch timing did not make much difference for people with other genetic variations.)

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